Articles

- Cell
- Volume 184
- Number 13
- June 24, 2021
Novel energy-expenditure target
Inducible genetic activation of GPR3 in brown adipocytes of obese mice robustly boosted energy expenditure that drove decreases in fat mass and overall bodyweight, and completely corrected glycemic control without affecting the cardiovascular system.
Findings from patient-derived cells validated GPR3 as a powerful activator of human brown adipocytes and indicate that GPR3 might offer the opportunity to safely and potently leverage the calorie-burning power of these highly specialized fat cells to counteract metabolic disease.
The scientific work was done in collaboration with the Gerhart-Hines laboratory at the University of Copenhagen and an international team of researchers from Europe and the US. The resulting paper was published in Cell and featured on the cover of the July 2021 issue.